Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease
نویسندگان
چکیده
منابع مشابه
Interleukin-6 sequence variants are not associated with prostate cancer risk.
Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Radiation Sciences, Oncology, University of Umeå, Umeå, Sweden; Regional Oncologic Center Stockholm-Gotland, Karolinska Sjukhuset, Stockholm, Sweden; and Department of Urology, Johns Hop...
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We conducted this case-control study to investigate the genetic role of IL-1β+3954C/T, IL-6-174G/C, IL-6-572C/G, IL-10-1082A/G, and IL-10-819C/T in the development of coronary artery disease (CAD) in a Chinese population. Polymorphisms IL-1β+3954C/T, IL-6-174G/C, IL-6-572C/G, IL-10-1082A/G, and IL-10-819C/T were determined by polymerase chain reaction restriction fragment length polymorphism as...
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Background and Aims: One of the most important genes involved in Alzheimer's disease (AD) is the presenilin2 (PSEN2) gene, which is one of the main constituents of the gamma-secretase complex. Mutations in this gene promote the formation of amyloid plaques resulting in AD. The study aimed to evaluate the mutation variant in exon 6 of the PSEN2 gene in patients with Late-Onset AD (LOAD). Due to ...
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Curcumin has been shown to have numerous cytotoxic effects on cancer stem cells (CSCs). This is due to its suppression of the release of cytokines, particularly interleukin (IL)-6, IL-8 and IL-1, which stimulate CSCs, and also to its effects at multiple sites along CSC pathways, such as Wnt, Notch, Hedgehog and FAK. In spite of its multiple actions targeting CSCs, curcumin has little toxicity a...
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ژورنال
عنوان ژورنال: Journal of Neuroinflammation
سال: 2012
ISSN: 1742-2094
DOI: 10.1186/1742-2094-9-21